Tetrazzini is a creamy pasta casserole typically made with spaghetti or egg noodles, shredded poultry or seafood (like turkey or chicken), mushrooms, and a rich béchamel or cream sauce, topped with grated cheese and sometimes breadcrumbs, then baked until golden. It was invented in the early 1900s in San Francisco, likely at the Palace Hotel, and named after the famous Italian opera singer Luisa Tetrazzini. While not an Italian dish, it reflects early 20th-century American cuisine's love of indulgent, European-inspired comfort food—especially popular as a way to use leftover turkey after Thanksgiving.

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